Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but …

Over the past decade, the identification of cancer-associated factors has been a subject of
primary interest not only for understanding the basic mechanisms of tumorigenesis but also …

Abstract ToppGene Suite (http://toppgene. cchmc. org; this web site is free and open to all
users and does not require a login to access) is a one-stop portal for (i) gene list functional …

Background Natural products have been an important source of lead compounds for drug
discovery. How to find and evaluate bioactive natural products is critical to the achievement …

Rapidly increasing amounts of molecular interaction data are being produced by various
experimental techniques and computational prediction methods. In order to gain insight into …

Background Numerous centrality measures have been introduced to identify “central” nodes
in large networks. The availability of a wide range of measures for ranking influential nodes …

The increasing availability of large network datasets along with the progresses in
experimental high-throughput technologies have prompted the need for tools allowing easy …

Connectivity plays a crucial role as agencies at the federal and state level focus on
expanding the public transit system to meet the demands of a multimodal transportation …

Everything is connected and thus networks are instrumental in not only modeling complex
systems with many components, but also accommodating knowledge about their …

Background Although most of the current disease candidate gene identification and
prioritization methods depend on functional annotations, the coverage of the gene functional …