Among the aromatic heterocycle rings, pyrazole–a five-membered ring with two adjacent
nitrogen atoms in its structure has been postulated as a potent candidate in the …

Herein, we report analogues of s‐indacene by the synthesis of novel indolizine derivatives.
Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl‐indolizine (4 …

Background Traditional approaches to drug development are costly and involve high risks.
The drug repurposing approach can be a valuable alternative to traditional approaches and …

Targeting DNA repair, like PARP-1 and TOPO-I, shows promise in cancer therapy. However,
resistance to single agents requires complex and costly combination strategies with …

Due to the poor metabolic conditions fomenting the emergence of the Warburg effect (WE)
phenotype, abnormal glycometabolism has become a unique and fundamental research …

Background Cyclooxygenase enzyme is frequently overexpressed in various types of cancer
and found to play a crucial role in poor prognosis in cancer patients. In current research, we …

Novel series of heterocycliccompounds pairing hybrids pyrazole, naphthalene and
pyrazoline/thiazoldinemoieties were synthesized. The starting compounds pyrazolyl …

Simple Summary Despite their documented antitumor effects, thienopyrazole-based
compounds remain an underexplored class of molecules. In this study, a screening of 2000 …

Chagas disease, a century-old disease that mainly affects the impoverished population in
Latin America, causes high morbidity and mortality in endemic countries. The available …

Structural diversity, pharmacological relevance, and the ability to include N-containing
heterocyclic derivatives through medicinal chemistry make these heterocyclic compounds …