Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Cancer progression is primarily caused by interactions between transformed cells and the
components of the tumor microenvironment (TME). TAMs (tumor-associated macrophages) …

Abstract cGAS-STING pathway, as an essential intracellular immune response pathway, has
attracted much attention in tumor immunotherapy. However, low metabolic stability of …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of
cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work …

Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

Elimination of cancer stem cells (CSCs) and reinvigoration of antitumor immunity remain
unmet challenges for cancer therapy. Tumor-associated macrophages (TAMs) constitute the …

Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel
their own growth and license tumor immune evasion. However, the relationships between …

Profiting from the sustained clinical improvement and prolonged patient survival, immune
checkpoint blockade of programmed cell death protein 1 (PD-1)/programmed death-ligand 1 …