Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …

In the auditory system, type I spiral ganglion neurons (SGNs) convey complex acoustic
information from inner hair cells (IHCs) to the brainstem. Although SGNs exhibit variation in …

Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to
the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that …

Normal hearing and synaptic transmission at afferent auditory inner hair cell (IHC) synapses
require otoferlin. Deafness DFNB 9, caused by mutations in the OTOF gene encoding …

Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle
requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non …

Cochlear inner hair cells (IHC s) develop from pre‐sensory pacemaker to sound transducer.
Here, we report that this involves changes in structure and function of the ribbon synapses …

We describe the development of the human inner ear with the invagination of the otic vesicle
at 4 weeks gestation (WG), the growth of the semicircular canals from 5 WG, and the …

Ribbon synapses of cochlear inner hair cells (IHCs) undergo molecular assembly and
extensive functional and structural maturation before hearing onset. Here, we characterized …

We studied the role of the synaptic ribbon for sound encoding at the synapses between
inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE …