Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Immunotherapy, specifically the introduction of immune checkpoint inhibitors, has
transformed the treatment of cancer, enabling long-term tumour control even in individuals …

The advent of antibody-based cancer therapeutics has led to the concomitant rise in the
development of companion diagnostics for these therapies, particularly nuclear imaging …

The homing molecule, L-selectin (CD62L), is commonly used as a T cell activation marker,
since expression is downregulated following engagement of the T cell receptor. Studies in …

Molecular imaging—and especially Positron Emission Tomography (PET)—is of increasing
importance for the diagnosis of various diseases and thus is experiencing increasing …

The recent clinical success of cancer immunotherapy has renewed interest in the
development of tools to image the immune system. In general, immunotherapies attempt to …

During the last decade, the discovery of critical tumor targets has boosted the design of
targeted therapeutic agents with monoclonal antibodies (mAbs) and tyrosine kinase …

Tracking of immune cells in vivo is a crucial tool for development and optimization of cell‐
based therapy. Techniques for tracking immune cells have been applied widely for …

In this work the production of 64Cu via the 64Ni (p, n) 64Cu reaction with optimized
conditions for low current irradiation is presented. Different target setups and cleaning steps …

Cancer immunotherapy has led to impressive antitumor effects. However, not all patients
respond to immunotherapy, serious toxicity can occur and combination therapy may be …