Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted,
damaged, or infected cells in multicellular organisms and also in diverse biological …
damaged, or infected cells in multicellular organisms and also in diverse biological …
BCL-2 family antagonists for cancer therapy
Overexpression of members of the BCL-2 family of pro-survival proteins is commonly
associated with unfavourable pathogenesis in cancer. The convergence of cytotoxic stress …
associated with unfavourable pathogenesis in cancer. The convergence of cytotoxic stress …
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Abstract MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of
multiple cell lineages, is also among the most highly amplified genes in cancer. Although …
multiple cell lineages, is also among the most highly amplified genes in cancer. Although …
BCL-2 family proteins: critical checkpoints of apoptotic cell death
NN Danial - Clinical cancer research, 2007 - AACR
Apoptosis is a morphologically distinct form of programmed cell death essential for normal
development and tissue homeostasis. Aberrant regulation of this pathway is linked to …
development and tissue homeostasis. Aberrant regulation of this pathway is linked to …
Bcl2 family proteins in carcinogenesis and the treatment of cancer
Deregulation of Bcl2 family members is a frequent feature of human malignant diseases and
causal for therapy resistance. A number of studies have recently shed light onto the role of …
causal for therapy resistance. A number of studies have recently shed light onto the role of …
Delving deeper: MCL-1's contributions to normal and cancer biology
BCL-2 molecules are regulators of programmed cell death and defects in this pathway
contribute to human diseases. One family member, MCL-1, is unique because its expression …
contribute to human diseases. One family member, MCL-1, is unique because its expression …
Targeting Mcl-1 for the therapy of cancer
Introduction: Human cancers are genetically and epigenetically heterogeneous and have
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer
DJ Stewart - Critical reviews in oncology/hematology, 2010 - Elsevier
While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …
Design, synthesis, chemical and biochemical insights into novel hybrid spirooxindole-based p53-MDM2 inhibitors with potential Bcl2 signaling attenuation
The tumor resistance to p53 activators posed a clinical challenge. Combination studies
disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and …
disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and …
Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next …
Despite the achieved progress in develo** efficient MDM2-p53 protein-protein interaction
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …
inhibitors (MDM2 inhibitors), the acquired resistance of tumor cells to such p53 activators …