Generation of the serine proteinase plasmin from the extracellular zymogen plasminogen
can be catalyzed by either of two other serine proteinases, the urokinase-and tissue-type …

The prevailing view is that disulfide bonds have been added during evolution to enhance
the stability of proteins that function in a fluctuating cellular environment. However, recent …

Targeted mutagenesis has allowed investigators to perform controlled experiments in
mammals and determine the contribution of individual proteins to physiologic and pathologic …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

Angiostatin, a proteolytic fragment of plasminogen, is a potent antagonist of angiogenesis
and an inhibitor of endothelial cell migration and proliferation. To determine whether the …

Angiostatin, a cleavage product of plasminogen, has been shown to inhibit endothelial cell
proliferation and metastatic tumor cell growth. Recently, the production of angiostatin has …

Cell-surface tissue factor (TF) binds the serine protease factor VIIa to activate coagulation or,
alternatively, to trigger signaling through the G protein-coupled, protease-activated receptor …

The process of angiogenesis plays an important role in many physiological and pathological
conditions. Inhibition of endothelial cell (EC) apoptosis providing EC survival is thought to be …

Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma,
characterized by progressive accumulation of scar tissue and myofibroblast activation after …

Angiostatin is one of the most potent inhibitors of angiogenesis. Reports have shown that
metalloelastase, pancreas elastase, plasmin reductase, and plasmin convert plasminogen …