Abstract γδ T cells are a unique T cell subpopulation that are rare in secondary lymphoid
organs but enriched in many peripheral tissues, such as the skin, intestines and lungs. By …

The immune system has coevolved with extensive microbial communities living on barrier
sites that are collectively known as the microbiota. It is increasingly clear that microbial …

The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

The increasing prevalence of dry eye syndrome in aging and digital societies compromises
long‐term contact lens (CL) wear and forces users to regular eye drop instillation to alleviate …

Mammals co-exist with resident microbial ecosystem that is composed of an incredible
number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident …

The IL-1 signaling pathway has been shown to play a critical role in the pathogenesis of
chronic, autoinflammatory skin diseases such as psoriasis. However, the exact cellular and …

The eye is a sensory organ exposed to the environment and protected by a mucosal tissue
barrier. While it shares a number of features with other mucosal tissues, the ocular mucosal …

The ocular surface flora perform an important role in the defense mechanisms of the ocular
surface system. Its regulation of the immunological activity and the barrier effect against …

As interest in γδ T cells grows rapidly, what key points are emerging, and where is caution
warranted? γδ T cells fulfill critical functions, as reflected in associations with vaccine …