The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The advent of glass-based microfluidic devices further revolutionized in microfluidic
technology due to the several advantageous properties in terms of photonics, electronics …

Introduction: Western blotting is one of the most commonly used techniques in molecular
biology and proteomics. Since western blotting is a multistep protocol, variations and errors …

Tissue diagnosis is important during surgical excision of solid tumors for margin evaluation.
Conventional histopathologic methods rely heavily on image-based visual diagnosis by …

This protocol describes how to perform western blotting on individual cells to measure cell-to-
cell variation in protein expression levels and protein state. Like conventional western …

The inherent heterogeneity in cell populations has become of great interest and importance
as analytical techniques have improved over the past decades. With the advent of …

The commonly existing cellular heterogeneity plays a critical role in biological processes
such as embryonic development, cell differentiation, and disease progress. Single‐cell …

Advances of analytical methods and emerging microfluidic tools have made it possible to
investigate biological processes in living organisms in detail and reach sensitivities sufficient …

Western blot (WB) or immunoblot is a workhorse method. It is commonly used by biologists
for study of different aspects of protein biomolecules. In addition, it has been widely used in …

Simple Summary This review discusses the heterogeneity of breast cancer and strategies to
understand it using multi-omics profiling methods at the traditional bulk and single-cell …