Microglia and neuroinflammation: crucial pathological mechanisms in traumatic brain injury-induced neurodegeneration

F Shao, X Wang, H Wu, Q Wu, J Zhang - Frontiers in Aging …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is one of the most common diseases in the central nervous
system (CNS) with high mortality and morbidity. Patients with TBI usually suffer many …

Cannabidiol for neurodegenerative disorders: A comprehensive review

S Bhunia, N Kolishetti, AY Arias, A Vashist… - Frontiers in …, 2022 - frontiersin.org
Despite the significant advances in neurology, the cure for neurodegenerative conditions
remains a formidable task to date. Among various factors arising from the complex etiology …

Rice bran: From waste to nutritious food ingredients

BL Tan, ME Norhaizan, LC Chan - Nutrients, 2023 - mdpi.com
Rice (Oryza sativa L.) is a principal food for more than half of the world's people. Rice is
predominantly consumed as white rice, a refined grain that is produced during the rice …

[HTML][HTML] PPAR gamma: from definition to molecular targets and therapy of lung diseases

MV Carvalho, CF Gonçalves-de-Albuquerque… - International Journal of …, 2021 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor
superfamily that regulate the expression of genes related to lipid and glucose metabolism …

PPARs and their neuroprotective effects in Parkinson's disease: a novel therapeutic approach in α-synucleinopathy?

I Pérez-Segura, A Santiago-Balmaseda… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is the most common α-synucleinopathy worldwide. The
pathognomonic hallmark of PD is the misfolding and propagation of the α-synuclein (α-syn) …

[HTML][HTML] Oxidative stress and mitochondrial complex I dysfunction correlate with neurodegeneration in an α-synucleinopathy animal model

A Morales-Martínez, PA Martínez-Gómez… - International Journal of …, 2022 - mdpi.com
The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which
Parkinson's disease (PD) is the most common worldwide, characterized by the accumulation …

Quercetin potentiates the hepatoprotective effect of sildenafil and/or pentoxifylline against intrahepatic cholestasis: Role of Nrf2/ARE, TLR4/NF-κB, and NLRP3/IL-1β …

MA Fawzy, G Nasr, FEM Ali, M Fathy - Life Sciences, 2023 - Elsevier
Aim Intrahepatic cholestasis is a common pathological condition of several types of liver
disorders. In this study, we aimed to investigate the regulatory effects of quercetin (QU) on …

Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy

M Fantacuzzi, R Amoroso, S Carradori… - European Journal of …, 2022 - Elsevier
Neurodegenerative diseases (NDs) are characterized by gradual and progressive loss of
selectively vulnerable populations of neurons, including death of neurons in different …

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

AAB Lataliza, PM de Assis… - Phytotherapy …, 2021 - Wiley Online Library
Rosmarinic acid (RA), an ester of caffeic acid and 3, 4‐dihydroxyphenyllactic acid, has anti‐
inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug …

[HTML][HTML] Anti-cholinesterase, anti-inflammatory and antioxidant properties of Combretum micranthum G. Don: Potential implications in neurodegenerative disease

M Kpemissi, YT Kantati, VP Veerapur… - IBRO Neuroscience …, 2023 - Elsevier
Background Brain damage is a severe and common pathology that leads to life-threatening
diseases. Despite development in the research, the medical evidence of the effectiveness of …