Regulation of microtubule dynamics, mechanics and function through the growing tip
NB Gudimchuk, JR McIntosh - Nature reviews Molecular cell biology, 2021 - nature.com
Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …
The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …
division, sha**, motility and intracellular transport. Despite their functional heterogeneity …
Separating the effects of nucleotide and EB binding on microtubule structure
R Zhang, B LaFrance, E Nogales - … of the National Academy of Sciences, 2018 - pnas.org
Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …
hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within …
Microtubules: From understanding their dynamics to using them as potential therapeutic targets
Y Ilan - Journal of cellular physiology, 2019 - Wiley Online Library
Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …
Microtubule structure by cryo-EM: snapshots of dynamic instability
SW Manka, CA Moores - Essays in biochemistry, 2018 - portlandpress.com
The development of cryo-electron microscopy (cryo-EM) allowed microtubules to be
captured in their solution-like state, enabling decades of insight into their dynamic …
captured in their solution-like state, enabling decades of insight into their dynamic …
Taxol acts differently on different tubulin isotypes
YM Chew, RA Cross - Communications biology, 2023 - nature.com
Taxol is a small molecule effector that allosterically locks tubulin into the microtubule lattice.
We show here that taxol has different effects on different single-isotype microtubule lattices …
We show here that taxol has different effects on different single-isotype microtubule lattices …
What could go wrong? A practical guide to single-particle cryo-EM: from biochemistry to atomic models
MA Cianfrocco, EH Kellogg - Journal of Chemical Information and …, 2020 - ACS Publications
Cryo-electron microscopy (cryo-EM) has enjoyed explosive recent growth due to
revolutionary advances in hardware and software, resulting in a steady stream of long …
revolutionary advances in hardware and software, resulting in a steady stream of long …
Tubulin isotype regulation maintains asymmetric requirement for α-tubulin over β-tubulin
LC Wethekam, JK Moore - Journal of Cell Biology, 2023 - rupress.org
How cells regulate α-and β-tubulin to meet the demand for αβ-heterodimers and avoid
consequences of monomer imbalance is not understood. We investigate the role of gene …
consequences of monomer imbalance is not understood. We investigate the role of gene …
Microtubule lattice plasticity
RA Cross - Current Opinion in Cell Biology, 2019 - Elsevier
In classical microtubule dynamic instability, the dynamics of the built polymer depend only
on the nucleotide state of its individual tubulin molecules. Recent work is overturning this …
on the nucleotide state of its individual tubulin molecules. Recent work is overturning this …
Axonemal doublet microtubules can split into two complete singlets in human sperm flagellum tips
Motile flagella are crucial for human fertility and embryonic development. The distal tip of the
flagellum is where growth and intra‐flagellar transport are coordinated. In most model …
flagellum is where growth and intra‐flagellar transport are coordinated. In most model …