Deep brain stimulation has been extensively studied as a therapeutic option for treatment-
resistant depression (TRD). DBS across different targets is associated with on average 60 …

The field of stereotactic neurosurgery developed more than 70 years ago to address a
therapy gap for patients with severe psychiatric disorders. In the decades since, it has …

The success of deep brain stimulation (DBS) for treating Parkinson's disease has led to its
application to several other disorders, including treatment-resistant depression. Results with …

At the group-level, deep brain stimulation leads to significant therapeutic benefit in a
multitude of neurological and neuropsychiatric disorders. At the single-patient level …

Despite increasing prevalence and huge personal and societal burden, psychiatric diseases
still lack treatments which can control symptoms for a large fraction of patients. Increasing …

Neuropsychiatric disorders such as major depression are a leading cause of disability
worldwide with standard treatments, including psychotherapy or medication, failing many …

Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

Background Disorders of mood and cognition are prevalent, disabling, and notoriously
difficult to treat. Fueling this challenge in treatment is a significant gap in our understanding …

The rewards that we get from our choices and actions can have a major influence on our
future behavior. Understanding how reward biasing of behavior is implemented in the brain …

Deep brain stimulation (DBS) is an effective therapy for various neurologic and
neuropsychiatric disorders, involving chronic implantation of electrodes into target brain …