Biomarker-based staging of Alzheimer disease: rationale and clinical applications
Disease staging, whereby the spatial extent and load of brain pathology are used to
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …
estimate the severity of Alzheimer disease (AD), is pivotal to the gold-standard …
Blood biomarkers to detect Alzheimer disease in primary care and secondary care
Importance An accurate blood test for Alzheimer disease (AD) could streamline the
diagnostic workup and treatment of AD. Objective To prospectively evaluate a clinically …
diagnostic workup and treatment of AD. Objective To prospectively evaluate a clinically …
Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age–related tauopathy and Alzheimer's disease
KA Josephs, N Tosakulwong, SD Weigand… - Science translational …, 2024 - science.org
[18F]-Flortaucipir positron emission tomography (PET) is considered a good biomarker of
Alzheimer's disease. However, it is unknown how flortaucipir is associated with the …
Alzheimer's disease. However, it is unknown how flortaucipir is associated with the …
Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum
D Liu, J Lu, L Wei, M Yao, H Yang, P Lv… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is a prevalent form of dementia that affects an estimated 32 million
individuals globally. Identifying early indicators is vital for screening at-risk populations and …
individuals globally. Identifying early indicators is vital for screening at-risk populations and …
[PDF][PDF] A data-driven study of Alzheimer's disease related amyloid and tau pathology progression
Amyloid-β is thought to facilitate the spread of tau throughout the neocortex in Alzheimer's
disease, though how this occurs is not well understood. This is because of the spatial …
disease, though how this occurs is not well understood. This is because of the spatial …
Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer's disease continuum
AE Denning, R Ittyerah, LM Levorse… - Acta …, 2024 - Springer
The medial temporal lobe (MTL) is a hotspot for neuropathology, and measurements of MTL
atrophy are often used as a biomarker for cognitive decline associated with …
atrophy are often used as a biomarker for cognitive decline associated with …
Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer's disease
SN Roemer-Cassiano, F Wagner… - Science Translational …, 2025 - science.org
In Alzheimer's disease (AD), amyloid-β (Aβ) triggers the aggregation and spreading of tau
pathology, which drives neurodegeneration and cognitive decline. However, the …
pathology, which drives neurodegeneration and cognitive decline. However, the …
Review on anti-alzheimer drug development: approaches, challenges and perspectives
AE Abdallah - RSC advances, 2024 - pubs.rsc.org
Alzheimer is an irreversible progressive neurodegenerative disease that causes failure of
cerebral neurons and disability of the affected person to practice normal daily life activities …
cerebral neurons and disability of the affected person to practice normal daily life activities …
Towards in vivo PET imaging of primary age-related tauopathy
Towards in vivo PET imaging of primary age-related tauopathy | Brain | Oxford Academic Skip to
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[18F] 2-fluoro-2-deoxy-sorbitol ([18F] FDS) PET imaging repurposed for quantitative estimation of blood-brain barrier permeability in a rat model of Alzheimer's disease
A Soyer, S Goutal, S Leterrier, S Marie, B Larrat… - Annales …, 2024 - Elsevier
Numerous studies suggest that blood-brain barrier (BBB) dysfunction may contribute to the
progression of Alzheimer's disease (AD). Clinically available neuroimaging methods are …
progression of Alzheimer's disease (AD). Clinically available neuroimaging methods are …