Cardiovascular disease, which can lead to angina and shortness of breath, remains one of
the most serious threats to human health. Owing to its imperceptible symptoms, it is difficult …

In recent years, the heme catabolic pathway is considered to play an important regulatory
role in cell protection, apoptosis, inflammation, and other physiological and pathological …

Objectives Increasing evidence suggests that oxidative stress may play a key role in joint
destruction due to rheumatoid arthritis (RA). The aim of this study was to elucidate the role of …

Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or
clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and …

Our previous report has shown that FGF21 has anti-inflammatory properties in a collagen-
induced arthritis (CIA) model. In this study, the underlying molecular mechanisms of action …

Novel therapies for rheumatoid arthritis also include the use of naturally occurring
compounds possessing antioxidant properties. In the present work, the effects of oral …

Objective—Activation of peroxisome proliferator-activated receptors (PPARs) by lipid-
lowering fibrates and insulin-sensitizing thiazolidinediones inhibits vascular inflammation …

Joint conditions pose an important public health problem as they are a leading cause of
pain, functional limitation and physical disability. Oxidative stress is related to the …

Background As a prolonged autoimmune disorder, rheumatoid arthritis (RA) is characterised
by synovial hyperplasia and the erosion of bone and cartilage. Magnoflorine (MAG) is the …

The nuclear factor erythroid 2-related factor (Nrf2) signaling pathway has recently emerged
as a novel therapeutic target in treating various diseases. Therefore, the present study …