This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …

Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in
all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel …

The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP
superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate …

How cells sense hydraulic pressure and make directional choices in confinement remains
elusive. Using trifurcating Ψ-like microchannels of different hydraulic resistances and cross …

Aqueous humor drainage from the anterior eye determines intraocular pressure (IOP) under
homeostatic and pathological conditions. Swelling of the trabecular meshwork (TM) alters its …

Highlights•Fatty acids alter membrane mechanics and modify ion channel function.•Fatty
acids directly interact with ion channels and regulate their function.•Structural studies reveal …

In healthy connective tissues, mechanosensors trigger the generation of Ca2+ signals,
which enable cells to maintain the structure of the fibrillar collagen matrix through …

Ion channels are well placed to transduce environmental cues into signals used by cells to
generate a wide range of responses, but little is known about their role in the regulation of …