Oesophageal cancer is a global health problem; in 2018 there were more than 572,000
people newly diagnosed with oesophageal cancer worldwide. There are two main …

Gastric cancer is the second most common cause of cancer-related deaths in the world, the
epidemiology of which has changed within last decades. A trend of steady decline in gastric …

Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's
population. Infection with H. pylori causes chronic inflammation and significantly increases …

The involvement of the prostaglandin E2 (PGE2) system in cancer progression has long
been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be
involved in the inflammatory and innate immune responses. Although the importance of NF …

Since the early 1970s, the incidence of oesophageal adenocarcinoma has increased
dramatically in most Western populations. In contrast, the incidence of oesophageal …

The incidence and mortality of gastric cancer have fallen dramatically in US and elsewhere
over the past several decades. Nonetheless, gastric cancer remains a major public health …

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in
the stomach, only a small fraction of colonized individuals develop this common malignancy …

Clinical guidelines for prophylactic aspirin use currently only consider the cardiovascular
benefits of aspirin, weighed against the potential harm from aspirin-induced bleeding. Daily …