Metabolic burden is defined by the influence of genetic manipulation and environmental
perturbations on the distribution of cellular resources. The rewiring of microbial metabolism …

Control interventions steer the evolution of molecules, viruses, microorganisms or other cells
towards a desired outcome. Applications range from engineering biomolecules and …

Life-like systems need to maintain a basal metabolism, which includes importing a variety of
building blocks required for macromolecule synthesis, exporting dead-end products, and …

Artificial microbial consortia seek to leverage division-of-labour to optimize function and
possess immense potential for bioproduction. Co-culturing approaches, the preferred mode …

Careful consideration of how we approach design is crucial to all areas of biotechnology.
However, choosing or develo** an effective design methodology is not always easy as …

Synthetic biology (SynBio) has attracted like no other recent development the attention not
only of Life Science researchers and engineers but also of intellectuals, technology think …

A neutral network connects all genotypes with equivalent phenotypes in a fitness landscape
and plays an important role in the mutational robustness and evolvability of biomolecules. In …

After 2 decades of growth and success, synthetic biology has now become a mature field
that is driving significant innovation in the bioeconomy and pushing the boundaries of the …

The planetary biosphere is powered by a suite of key metabolic innovations that emerged
early in the history of life. However, it is unknown whether life has always followed the same …

Synthetic genomics seeks to design and construct entire genomes to mechanistically dissect
fundamental questions of genome function and to engineer organisms for diverse …