microRNA‐based diagnostic and therapeutic applications in cancer medicine

LF Sempere, AS Azmi, A Moore - Wiley Interdisciplinary …, 2021 - Wiley Online Library
It has been almost two decades since the first link between microRNAs and cancer was
established. In the ensuing years, this abundant class of short noncoding regulatory RNAs …

Peptide nucleic acid (PNA) and its applications in chemical biology, diagnostics, and therapeutics

J Saarbach, PM Sabale, N Winssinger - Current opinion in chemical …, 2019 - Elsevier
Peptide nucleic acid (PNA) stands as one of the most successful artificial oligonucleotide
mimetics. Salient features include the stability of hybridization complexes (either as …

[HTML][HTML] Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

R Mu, D Zhu, S Abdulmalik, S Wijekoon, G Wei… - Bioactive materials, 2024 - Elsevier
Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good
biodegradability, and easy functionalization, which promote their applications as versatile …

Therapeutic and diagnostic applications of antisense peptide nucleic acids

V MacLelland, M Kravitz, A Gupta - Molecular Therapy Nucleic Acids, 2024 - cell.com
Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …

The challenges and opportunities in the development of MicroRNA therapeutics: a multidisciplinary viewpoint

MY Momin, RR Gaddam, M Kravitz, A Gupta, A Vikram - Cells, 2021 - mdpi.com
microRNAs (miRs) are emerging as attractive therapeutic targets because of their small size,
specific targetability, and critical role in disease pathogenesis. However,< 20 miR targeting …

[HTML][HTML] Chemical approaches to discover the full potential of peptide nucleic acids in biomedical applications

N Brodyagin, M Katkevics, V Kotikam… - Beilstein journal of …, 2021 - beilstein-journals.org
Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

[HTML][HTML] Focus: genome editing: therapeutic peptide nucleic acids: principles, limitations, and opportunities

E Quijano, R Bahal, A Ricciardi… - The Yale journal of …, 2017 - ncbi.nlm.nih.gov
Since their invention in 1991, peptide nucleic acids (PNAs) have been used in a myriad of
chemical and biological assays. More recently, peptide nucleic acids have also been …

Unlocking the potential of chemically modified peptide nucleic acids for RNA-based therapeutics

SP Pradeep, S Malik, FJ Slack, R Bahal - RNA, 2023 - rnajournal.cshlp.org
RNA therapeutics have emerged as next-generation therapy for the treatment of many
diseases. Unlike small molecules, RNA targeted drugs are not limited by the availability of …

[HTML][HTML] Potential of peptide nucleic acids in future therapeutic applications

S Montazersaheb, MS Hejazi… - Advanced …, 2018 - ncbi.nlm.nih.gov
Peptide nucleic acids (PNA) are synthetic analog of DNA with a repeating N-(2-aminoethyl)-
glycine peptide backbone connected to purine and pyrimidine nucleobases via a linker …

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications

C Suparpprom, T Vilaivan - RSC Chemical Biology, 2022 - pubs.rsc.org
Peptide nucleic acid or PNA is a synthetic DNA mimic that contains a sequence of
nucleobases attached to a peptide-like backbone derived from N-2-aminoethylglycine. The …