OBJECTIVE: To review the literature on the role and regulation of chondrocyte terminal
differentiation (hypertrophy-like changes) in osteoarthritis (OA) and to integrate this in a …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Animal Models for the Study of Human Disease, Second Edition, provides needed
information on model sharing, animal alternatives, animal ethics and access to databanks of …

Osteoarthritis (OA) is among the most frequent diseases of the musculoskeletal system.
Degradation of cartilage extracellular matrix (ECM) is a hallmark of OA. During the …

Osteoarthritis (OA) is an extremely prevalent age-related condition. The economic and
societal burden due to the cost of symptomatic treatment, inability to work, joint replacement …

Whereas amphibians regenerate lost appendages spontaneously, mammals generally form
scars over the injury site through the process of wound repair. The MRL mouse strain is an …

The matrilins form a family of oligomeric extracellular adaptor proteins that are most strongly
expressed in cartilage but also present in many other extracellular matrices. Matrilins bind to …

Disturbances to the balance of protein synthesis, folding and secretion in the endoplasmic
reticulum (ER) induce stress and thereby the ER stress signaling (ERSS) response, which …

MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA)
pathogenesis. In our study, a real-time PCR assay revealed that miR-483-5p was …

Osteoarthritis is the most common arthritic condition, which involves progressive
degeneration of articular cartilage. The most recent accomplishments have significantly …