It is now accepted that nutrient abundance in the blood, especially glucose, leads to the
generation of reactive oxygen species (ROS), ultimately leading to increased oxidative …

Human alteration of the nitrogen cycle has resulted in steadily accumulating nitrate in our
water resources. The US maximum contaminant level and World Health Organization …

Man-made nitrogen fertilizers became widely used in US agriculture after WWII, providing an
inexpensive source of nitrogen and other plant nutrients that resulted in huge increases in …

Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a
fundamental role in endocrine pancreatic function. In the present study expression of PYY …

The frequency and duration of exposure to acrylamide (AA) from the environment and diet
are associated with a range of adverse health effects. However, whether long-term AA …

Background In the present study we assessed the impact of neuropeptide Y receptor
(NPYR) modulators, neuropeptide Y (NPY) and pancreatic polypeptide (PP), on islet …

Eicosanoids are major players in the pathogenesis of several common diseases, with either
overproduction or imbalance (eg between thromboxanes and prostacyclins) often leading to …

The novel human-derived pancreatic β-cell line, 1.1 B4 exhibits insulin secretion and β-cell
enriched gene expression. Recent investigations of the cellular responses of this novel cell …

Background Molecular mechanisms of toxicity and cell damage were investigated in the
novel human beta cell line, 1.1 B4, after exposure to proinflammatory cytokines—IL-1β, IFN …

Background Dietary polyphenols have been reported to have a variety of biological actions,
including anticarcinogenic and antioxidant activities. Aim of the study In the present study we …