Translational principles of deep brain stimulation

ML Kringelbach, N Jenkinson, SLF Owen… - Nature Reviews …, 2007 - nature.com
Deep brain stimulation (DBS) has shown remarkable therapeutic benefits for patients with
otherwise treatment-resistant movement and affective disorders. This technique is not only …

Deep brain stimulation for dystonia

M Vidailhet, MF Jutras, E Roze, D Grabli - Handbook of clinical neurology, 2013 - Elsevier
The few reported controlled studies show that bilateral stimulation of the globus pallidus
interna (GPi) is a safe and effective long-term treatment for hyperkinetic disorders. However …

Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial

J Volkmann, J Mueller, G Deuschl, AA Kühn… - The Lancet …, 2014 - thelancet.com
Background Cervical dystonia is managed mainly by repeated botulinum toxin injections.
We aimed to establish whether pallidal neurostimulation could improve symptoms in …

Pallidal deep-brain stimulation in primary generalized or segmental dystonia

A Kupsch, R Benecke, J Müller… - … England Journal of …, 2006 - Mass Medical Soc
Background Neurostimulation of the internal globus pallidus has been shown to be effective
in reducing symptoms of primary dystonia. We compared this surgical treatment with sham …

Bilateral, pallidal, deep-brain stimulation in primary generalised dystonia: a prospective 3 year follow-up study

M Vidailhet, L Vercueil, JL Houeto… - The Lancet …, 2007 - thelancet.com
Background We have previously reported the efficacy and safety of bilateral pallidal
stimulation for primary generalised dystonia in a prospective, controlled, multicentre study …

Systematic review of hardware-related complications of deep brain stimulation: do new indications pose an increased risk?

O Jitkritsadakul, R Bhidayasiri, SK Kalia, M Hodaie… - Brain Stimulation, 2017 - Elsevier
Abstract Introduction Deep Brain Stimulation (DBS) is an effective treatment extended
broadly to many neurological and psychiatric disorders. Nevertheless, complications may …

Which patients with dystonia benefit from deep brain stimulation? A metaregression of individual patient outcomes

C Andrews, I Aviles-Olmos, M Hariz… - Journal of Neurology …, 2010 - jnnp.bmj.com
There is substantial variability in the responsiveness of dystonia patients to deep brain
stimulation (DBS), presumably due to the multiple causes of dystonia. This article presents …

The Canadian multicentre study of deep brain stimulation for cervical dystonia

ZHT Kiss, K Doig-Beyaert, M Eliasziw, J Tsui… - Brain, 2007 - academic.oup.com
Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective
treatment for generalized dystonia. Its role in the management of other types of dystonia is …

Treatment of dystonia with deep brain stimulation

JL Ostrem, PA Starr - Neurotherapeutics, 2008 - Springer
Pallidal deep brain stimulation (DBS) is an established treatment option for medically
refractive dystonia. The mechanism by which globus pallidus pars interna (GPi) DBS …

Deep brain stimulation for primary generalized dystonia: long-term outcomes

IU Isaias, RL Alterman, M Tagliati - Archives of neurology, 2009 - jamanetwork.com
Background Pallidal deep brain stimulation (DBS) is the best therapeutic option for patients
with disabling primary generalized dystonia (PGD) that is refractory to medications …