Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Obesity has become a major worldwide health problem. In every single country in the world,
the incidence of obesity is rising continuously and therefore, the associated morbidity …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with
significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and …

Small extracellular vesicles (sEVs) such as exosomes are nanocarriers of proteins, RNAs
and DNAs. Isolation of pure sEV populations remains challenging, with reports of protein …

Two common features of dietary polyphenols have hampered our mechanistic
understanding of their beneficial effects for decades: targeting multiple organs and …

LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …

Publisher Summary This chapter focuses on the role of apoE in lipoprotein metabolism and
the most completely described function of the protein. Apolipoprotein E (apoE) is one of the …

Post-staining of extracellular vesicles (EVs) with lipid-anchored fluorophores (LAFs) such as
PKH67 is a widely used strategy for studying EVs but it is associated with several pitfalls …

The plasma clearance of intestinally derived remnant lipoproteins by the liver is a process
that likely involves three steps. Our model suggests that the initial rapid clearance by the …

Chylomicrons are formed in the intestine and transport dietary triglyceride to peripheral
tissues and cholesterol to the liver. The enzyme lipoprotein lipase, with apolipoprotein (apo) …