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Loo** the genome with SMC complexes
SMC (structural maintenance of chromosomes) protein complexes are an evolutionarily
conserved family of motor proteins that hold sister chromatids together and fold genomes …
conserved family of motor proteins that hold sister chromatids together and fold genomes …
The multi-functional Smc5/6 complex in genome protection and disease
XP Peng, X Zhao - Nature structural & molecular biology, 2023 - nature.com
Structural maintenance of chromosomes (SMC) complexes are ubiquitous genome
regulators with a wide range of functions. Among the three types of SMC complexes in …
regulators with a wide range of functions. Among the three types of SMC complexes in …
The Smc5/6 complex is a DNA loop-extruding motor
B Pradhan, T Kanno, M Umeda Igarashi, MS Loke… - Nature, 2023 - nature.com
Structural maintenance of chromosomes (SMC) protein complexes are essential for the
spatial organization of chromosomes. Whereas cohesin and condensin organize …
spatial organization of chromosomes. Whereas cohesin and condensin organize …
Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils
The structural maintenance of chromosomes (SMC) protein complexes—cohesin,
condensin, and the Smc5/6 complex (Smc5/6)—are essential for chromosome function. At …
condensin, and the Smc5/6 complex (Smc5/6)—are essential for chromosome function. At …
The SMC5/6 complex: folding chromosomes back into shape when genomes take a break
S Roy, H Adhikary, D D'Amours - Nucleic acids research, 2024 - academic.oup.com
High-level folding of chromatin is a key determinant of the shape and functional state of
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
chromosomes. During cell division, structural maintenance of chromosome (SMC) …
Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clam** enabled by multi-subunit conformational changes
Structural maintenance of chromosomes (SMC) complexes are essential for chromatin
organization and functions throughout the cell cycle. The cohesin and condensin SMCs fold …
organization and functions throughout the cell cycle. The cohesin and condensin SMCs fold …
[HTML][HTML] Mitotic chromosomes
JR Paulson, DF Hudson, F Cisneros-Soberanis… - Seminars in cell & …, 2021 - Elsevier
Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …
way since these iconic objects were first recognized more than 140 years ago, though many …
[HTML][HTML] Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
Epstein-Barr virus (EBV) persistently infects people worldwide. Delivery of∼ 170-kb EBV
genomes to nuclei and use of nuclear membrane-less replication compartments (RCs) for …
genomes to nuclei and use of nuclear membrane-less replication compartments (RCs) for …
Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy
LJ Grange, JJ Reynolds, F Ullah, B Isidor… - Nature …, 2022 - nature.com
Embryonic development is dictated by tight regulation of DNA replication, cell division and
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …
differentiation. Mutations in DNA repair and replication genes disrupt this equilibrium, giving …
Smc5/6 silences episomal transcription by a three-step function
F Abdul, A Diman, B Baechler… - Nature structural & …, 2022 - nature.com
In addition to its role in chromosome maintenance, the six-membered Smc5/6 complex
functions as a restriction factor that binds to and transcriptionally silences viral and other …
functions as a restriction factor that binds to and transcriptionally silences viral and other …