Signal transducer and activator of transcription 3 (STAT3) is a transcriptional factor involved
in almost all cancer hallmark features including tumor proliferation, metastasis …

It has been> 20 years since the formation of G-quadruplex (G4) secondary structures in
gene promoters was first linked to the regulation of gene expression. Since then, the …

Abstract Hypoxia‑ischemia (H‑I) is frequently observed in perinatal asphyxia and other
diseases. It can lead to serious cardiac injury, cerebral damage, neurological disability and …

Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint
blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway is activated in the majority of human cancers. This pathway is known to play a key …

Eukaryotic cells require sufficient oxygen (O2) for biological activity and survival. When the
oxygen demand exceeds its supply, the oxygen levels in local tissues or the whole body …

Recent clinical trials using rapalogues in tuberous sclerosis complex show regression in
volume of typically vascularised tumours including angiomyolipomas and subependymal …

Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …