Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Cytosolic delivery of proteins and peptides provides opportunities for effective disease
treatment, as they can specifically modulate intracellular processes. However, most of …

Oxidative stress and cell senescence are both important drivers of ageing and age-
associated disease and disability. In vitro, they are closely interconnected in a chicken-and …

Cellular senescence is a kind of cellular state triggered by endogenous or exogenous
stimuli, which is mainly characterized by stable cell cycle arrest and complex senescence …

Supramolecular chemistry focuses on the study of species joined by non-covalent
interactions, and therefore on dynamic and relatively ill-defined structures. Despite being a …

Ageing decreases the function of the immune system and increases susceptibility to some
chronic, infectious, and autoimmune diseases. Senescence cells, which produce …

To address the issue of nonspecific biodistribution of a chemotherapeutic drug, stable [2]
pseudorotaxane complexes (PK@ CAOPP and PR@ CAOPP) are used to demonstrate a …

Endometrial injury caused by intrauterine procedures can result in infertility and recurrent
miscarriages, and the current clinical treatments are inadequate for effective endometrial …

Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is
emerging as a new strategy for cancer treatment. Exogenous and endogenous stressors can …

Supramolecular peptide hydrogels (SPHs) consist of peptides containing hydrogelators and
functional epitopes, which can first self-assemble into nanofibers and then physically …