Method to diversify cyanine chromophore functionality enables improved biomolecule tracking and intracellular imaging
Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite
broad use, there are only a few synthetic methods to assemble these molecules, and each …
broad use, there are only a few synthetic methods to assemble these molecules, and each …
Steric protection of near-infrared fluorescent dyes for enhanced bioimaging
Near-fluorescent (NIR) dyes that absorb and emit light in the wavelength range of 650–1700
nm are well-suited for bioimaging due to the improved image contrast and increased …
nm are well-suited for bioimaging due to the improved image contrast and increased …
Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …
Structure–activity relationships of antibody-drug conjugates: a systematic review of chemistry on the Trastuzumab scaffold
Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that
seek to overcome the low therapeutic index of conventional cytotoxic agents. However …
seek to overcome the low therapeutic index of conventional cytotoxic agents. However …
Norcyanine-carbamates are versatile near-infrared fluorogenic probes
SM Usama, F Inagaki, H Kobayashi… - Journal of the …, 2021 - ACS Publications
Fluorogenic probes in the near-infrared (NIR) region have the potential to provide stimuli-
dependent information in living organisms. Here, we describe a new class of fluorogenic …
dependent information in living organisms. Here, we describe a new class of fluorogenic …
Near-infrared dye IRDye800CW-NHS coupled to Trastuzumab for near-infrared II fluorescence imaging in tumor xenograft models of HER-2-positive breast cancer
J **ao, S Qiu, Q Ma, S Bai, X Guo… - Journal of Materials …, 2023 - pubs.rsc.org
Near-infrared II fluorescent probes targeting tumors for diagnostic purposes have received
much attention in recent years. In this study, a fluorescent probe for the NIR-II was …
much attention in recent years. In this study, a fluorescent probe for the NIR-II was …
Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody–Drug Conjugate Linker Chemistry
Antibody–drug conjugates (ADCs) are a rapidly emerging therapeutic platform. The
chemical linker between the antibody and the drug payload plays an essential role in the …
chemical linker between the antibody and the drug payload plays an essential role in the …
Generation and Characterization of Novel Pan‐Cancer Anti‐uPAR Fluorescent Nanobodies as Tools for Image‐Guided Surgery
Ł Mateusiak, S Floru, TWM De Groof… - Advanced …, 2024 - Wiley Online Library
Fluorescence molecular imaging plays a vital role in image‐guided surgery. In this context,
the urokinase plasminogen activator receptor (uPAR) is an interesting biomarker enabling …
the urokinase plasminogen activator receptor (uPAR) is an interesting biomarker enabling …
Molecular Engineering of Sulfone-Xanthone Chromophore for Enhanced Fluorescence Navigation
H Zhang, FF **ang, YZ Liu, YJ Chen, DH Zhou, YH Liu… - JACS Au, 2023 - ACS Publications
Enriching the palette of high-performance fluorescent dyes is vital to support the frontier of
biomedical imaging. Although various rhodamine skeletons remain the premier type of small …
biomedical imaging. Although various rhodamine skeletons remain the premier type of small …
Targetable Conformationally Restricted Cyanines Enable Photon‐Count‐Limited Applications
P Eiring, R McLaughlin, SS Matikonda… - Angewandte Chemie …, 2021 - Wiley Online Library
Cyanine dyes are exceptionally useful probes for a range of fluorescence‐based
applications, but their photon output can be limited by trans‐to‐cis photoisomerization. We …
applications, but their photon output can be limited by trans‐to‐cis photoisomerization. We …