Method to diversify cyanine chromophore functionality enables improved biomolecule tracking and intracellular imaging

SM Usama, SC Marker, DH Li… - Journal of the …, 2023 - ACS Publications
Heptamethine indocyanines are invaluable probes for near-infrared (NIR) imaging. Despite
broad use, there are only a few synthetic methods to assemble these molecules, and each …

Steric protection of near-infrared fluorescent dyes for enhanced bioimaging

SSR Kommidi, KM Atkinson, BD Smith - Journal of Materials Chemistry …, 2024 - pubs.rsc.org
Near-fluorescent (NIR) dyes that absorb and emit light in the wavelength range of 650–1700
nm are well-suited for bioimaging due to the improved image contrast and increased …

Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging

DH Li, RS Gamage, AG Oliver, NL Patel… - Angewandte …, 2023 - Wiley Online Library
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared
(NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested …

Structure–activity relationships of antibody-drug conjugates: a systematic review of chemistry on the Trastuzumab scaffold

SS Matikonda, R McLaughlin, P Shrestha… - Bioconjugate …, 2022 - ACS Publications
Antibody-drug conjugates (ADCs) are a rapidly growing class of cancer therapeutics that
seek to overcome the low therapeutic index of conventional cytotoxic agents. However …

Norcyanine-carbamates are versatile near-infrared fluorogenic probes

SM Usama, F Inagaki, H Kobayashi… - Journal of the …, 2021 - ACS Publications
Fluorogenic probes in the near-infrared (NIR) region have the potential to provide stimuli-
dependent information in living organisms. Here, we describe a new class of fluorogenic …

Near-infrared dye IRDye800CW-NHS coupled to Trastuzumab for near-infrared II fluorescence imaging in tumor xenograft models of HER-2-positive breast cancer

J **ao, S Qiu, Q Ma, S Bai, X Guo… - Journal of Materials …, 2023 - pubs.rsc.org
Near-infrared II fluorescent probes targeting tumors for diagnostic purposes have received
much attention in recent years. In this study, a fluorescent probe for the NIR-II was …

Targeted Fluorogenic Cyanine Carbamates Enable In Vivo Analysis of Antibody–Drug Conjugate Linker Chemistry

SM Usama, SC Marker, DR Caldwell… - Journal of the …, 2021 - ACS Publications
Antibody–drug conjugates (ADCs) are a rapidly emerging therapeutic platform. The
chemical linker between the antibody and the drug payload plays an essential role in the …

Generation and Characterization of Novel Pan‐Cancer Anti‐uPAR Fluorescent Nanobodies as Tools for Image‐Guided Surgery

Ł Mateusiak, S Floru, TWM De Groof… - Advanced …, 2024 - Wiley Online Library
Fluorescence molecular imaging plays a vital role in image‐guided surgery. In this context,
the urokinase plasminogen activator receptor (uPAR) is an interesting biomarker enabling …

Molecular Engineering of Sulfone-Xanthone Chromophore for Enhanced Fluorescence Navigation

H Zhang, FF **ang, YZ Liu, YJ Chen, DH Zhou, YH Liu… - JACS Au, 2023 - ACS Publications
Enriching the palette of high-performance fluorescent dyes is vital to support the frontier of
biomedical imaging. Although various rhodamine skeletons remain the premier type of small …

Targetable Conformationally Restricted Cyanines Enable Photon‐Count‐Limited Applications

P Eiring, R McLaughlin, SS Matikonda… - Angewandte Chemie …, 2021 - Wiley Online Library
Cyanine dyes are exceptionally useful probes for a range of fluorescence‐based
applications, but their photon output can be limited by trans‐to‐cis photoisomerization. We …