RNA dynamics by NMR spectroscopy

M Marušič, J Schlagnitweit, K Petzold - ChemBioChem, 2019 - Wiley Online Library
An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

NMR studies of dynamic biomolecular conformational ensembles

DA Torchia - Progress in nuclear magnetic resonance spectroscopy, 2015 - Elsevier
Multidimensional heteronuclear NMR approaches can provide nearly complete sequential
signal assignments of isotopically enriched biomolecules. The availability of assignments …

Molecular dynamics simulations identify time scale of conformational changes responsible for conformational selection in molecular recognition of HIV-1 …

F Musiani, G Rossetti, L Capece… - Journal of the …, 2014 - ACS Publications
The HIV-1 Tat protein and several small molecules bind to HIV-1 transactivation responsive
RNA (TAR) by selecting sparsely populated but pre-existing conformations. Thus, a …

Ultraslow domain motions in HIV-1 TAR RNA revealed by solid-state deuterium NMR

W Huang, PS Emani, G Varani… - The Journal of Physical …, 2017 - ACS Publications
Intrinsic motions may allow HIV-1 transactivation response (TAR) RNA to change its
conformation to form a functional complex with the Tat protein, which is essential for viral …

RNA Characterization by Solid‐State NMR Spectroscopy

Y Yang, S Wang - Chemistry–A European Journal, 2018 - Wiley Online Library
The structures of RNAs, which play critical roles in various biological processes, provide
important clues and insights into the biological functions of these molecules. However, RNA …

[HTML][HTML] Advances in solid-state NMR methods for studying RNA structures and dynamics

J He, X Liu, S Wang - Magnetic Resonance Letters, 2024 - Elsevier
Ribonucleic acid (RNA) structures and dynamics play a crucial role in elucidating RNA
functions and facilitating the design of drugs targeting RNA and RNA-protein complexes …

Local isotropic diffusion approximation for coupled internal and overall molecular motions in NMR spin relaxation

ML Gill, AG Palmer III - The Journal of Physical Chemistry B, 2014 - ACS Publications
The present work demonstrates that NMR spin relaxation rate constants for molecules
interconverting between states with different diffusion tensors can be modeled theoretically …

Elucidating molecular motion through structural and dynamic filters of energy-minimized conformer ensembles

PS Emani, MF Bardaro Jr, W Huang… - The Journal of …, 2014 - ACS Publications
Complex RNA structures are constructed from helical segments connected by flexible loops
that move spontaneously and in response to binding of small molecule ligands and proteins …

Nuclear spin relaxation in liquids and gases

J Kowalewski - 2013 - books.rsc.org
This report reviews the progress in the field of NMR relaxation in fluids. The emphasis is on
comparatively simple liquids and solutions of physico-chemical and chemical interest, in …

Applications of spin–spin couplings

K Kamieńska-Trela, J Wójcik - 2014 - books.rsc.org
In this chapter, which is devoted to applications of spin–spin couplings, the literature
published between June 2012 and May 2013 has been reviewed. The data included has …