Molecular mechanisms of the microRNA-132 during tumor progressions
Cancer as one of the leading causes of human deaths has always been one of the main
health challenges in the world. Despite recent advances in therapeutic and diagnostic …
health challenges in the world. Despite recent advances in therapeutic and diagnostic …
Aberrant WNT/CTNNB1 signaling as a therapeutic target in human breast cancer: weighing the evidence
EH Van Schie, RE Van Amerongen - Frontiers in cell and …, 2020 - frontiersin.org
WNT signaling is crucial for tissue morphogenesis during development in all multicellular
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …
animals. After birth, WNT/CTNNB1 responsive stem cells are responsible for tissue …
Zilovertamab vedotin targeting of ROR1 as therapy for lymphoid cancers
Background Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein
present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate …
present on many cancers. Zilovertamab vedotin (ZV) is an antibody–drug conjugate …
ROR1-targeting switchable CAR-T cells for cancer therapy
The success of chimeric antigen receptor T cell (CAR-T) therapy in the treatment of
hematologic malignancies has prompted the development of numerous CAR-T …
hematologic malignancies has prompted the development of numerous CAR-T …
Prolonged hematologic toxicity following treatment with chimeric antigen receptor T cells in patients with hematologic malignancies
SJ Nagle, C Murphree, PW Raess… - American Journal of …, 2021 - Wiley Online Library
Chimeric antigen receptor T‐cell therapy (CAR T) is a novel intervention for
relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic …
relapsed/refractory diffuse large B‐cell lymphoma (R/R DLBCL) and other hematologic …
The RTK interactome: overview and perspective on RTK heterointeractions
Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
and survival. These single-pass membrane proteins are grouped into subfamilies based on …
Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research‐practice gaps, challenges, and insights
PP Zheng, J Li, JM Kros - Medicinal research reviews, 2018 - Wiley Online Library
To date, five cancer treatment modalities have been defined. The three traditional modalities
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …
of cancer treatment are surgery, radiotherapy, and conventional chemotherapy, and the two …
Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation
CE Correnti, GS Laszlo, WJ de van der Schueren… - Leukemia, 2018 - nature.com
The efficacy of early bispecific antibodies redirecting T-cells to eradicate cancer cells was
partly limited because of suboptimal effector cell engagement [1]. More efficient T-cell …
partly limited because of suboptimal effector cell engagement [1]. More efficient T-cell …
Develo** ROR1 targeting CAR-T cells against solid tumors in preclinical studies
B Lee, Y Wan, Z Chin, L Deng, M Deng, T Leung, J Hua… - Cancers, 2022 - mdpi.com
Simple Summary A ROR1 CAR-T cells derived from scFv of Zilovertamab with short IgG4
hinge spacer region, holds the specific cytotoxicities against a broad range of ROR1+ solid …
hinge spacer region, holds the specific cytotoxicities against a broad range of ROR1+ solid …
Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma
Simple Summary This research has been suggested after a gap was found in the previous
literature, and our hypothesis of the MMR vaccine being an oncolytic virus. The present …
literature, and our hypothesis of the MMR vaccine being an oncolytic virus. The present …