The pathogenesis of Parkinson's disease
Parkinson's disease is a progressive neurodegenerative condition associated with the
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
deposition of aggregated α-synuclein. Insights into the pathogenesis of Parkinson's disease …
The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure
J Hardy, V Escott-Price - Molecular Psychiatry, 2025 - nature.com
In this perspective we draw together the data from the genome wide association studies for
Alzheimer's disease, Parkinson's disease and the tauopathies and reach the conclusion that …
Alzheimer's disease, Parkinson's disease and the tauopathies and reach the conclusion that …
Transforming Parkinson's care in Africa (TraPCAf): protocol for a multimethodology national institute for health and care research global health research group project
Background Parkinson's disease (PD) is the second most common neurodegenerative
disorder and, according to the Global Burden of Disease estimates in 2015, was the fastest …
disorder and, according to the Global Burden of Disease estimates in 2015, was the fastest …
[HTML][HTML] Leveraging genetic diversity to understand monogenic Parkinson's disease's landscape in AfrAbia
W Mohamed - American Journal of Neurodegenerative Disease, 2023 - ncbi.nlm.nih.gov
Parkinson's disease may be caused by a single highly deleterious and penetrant pathogenic
variant in 5-10% of cases (monogenic). Research into these mutational disorders yields …
variant in 5-10% of cases (monogenic). Research into these mutational disorders yields …
The p.Gly2019Ser is a common LRRK2 pathogenic variant among Egyptians with familial and sporadic Parkinson's disease
The impact of LRRK2 variants on the risk of Parkinson's disease in Egyptians remains
unknown. We examined 1210 Egyptians (611 PD patients and 599 controls) from 16 …
unknown. We examined 1210 Egyptians (611 PD patients and 599 controls) from 16 …
Exploring the role of underrepresented populations in polygenic risk scores for neurodegenerative disease risk prediction
K Step, CAA Ndong Sima, I Mata… - Frontiers in Neuroscience, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by the progressive loss of neuronal
function and structure (Lamptey et al., 2022). Additionally, neurodegeneration is associated …
function and structure (Lamptey et al., 2022). Additionally, neurodegeneration is associated …
omicSynth: an open multi‐omic community resource for identifying druggable targets across neurodegenerative diseases
Background While there have been recent successes for Alzheimer's disease (AD)
therapeutics, successful disease‐modifying treatments for AD and neurodegenerative …
therapeutics, successful disease‐modifying treatments for AD and neurodegenerative …
[HTML][HTML] Ancient viral DNA in the human genome linked to neurodegenerative diseases
Abstract Background Human endogenous retroviruses (HERVs) are sequences in the
human genome that originated from infections with ancient retroviruses during our evolution …
human genome that originated from infections with ancient retroviruses during our evolution …
Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson's disease
P Saffie-Awad, I Elsayed, AO Sanyaolu, PW Crea… - 2023 - dro.deakin.edu.au
Evaluating the performance of polygenic risk profiling across diverse ancestry populations in
Parkinson’s disease Deakin University Browse Search File(s) under embargo Evaluating the …
Parkinson’s disease Deakin University Browse Search File(s) under embargo Evaluating the …
Insights into Ancestral Diversity in Parkinsons Disease Risk: A Comparative Assessment of Polygenic Risk Scores
Objectives To evaluate and compare different polygenic risk score (PRS) models in
predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the …
predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the …