The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

N Ricard, S Bailly, C Guignabert… - Nature Reviews Cardiology, 2021 - nature.com
Endothelial cells are at the interface between circulating blood and tissues. This position
confers on them a crucial role in controlling oxygen and nutrient exchange and cellular …

Biomaterials and tissue engineering approaches using glycosaminoglycans for tissue repair: Lessons learned from the native extracellular matrix

R Menezes, R Vincent, L Osorno, P Hu, TL Arinzeh - Acta biomaterialia, 2023 - Elsevier
Glycosaminoglycans (GAGs) are an important component of the extracellular matrix as they
influence cell behavior and have been sought for tissue regeneration, biomaterials, and …

Heparan sulfate biosynthesis and sulfation profiles as modulators of cancer signalling and progression

C Marques, CA Reis, RR Vivès, A Magalhães - Frontiers in oncology, 2021 - frontiersin.org
Heparan Sulfate Proteoglycans (HSPGs) are important cell surface and Extracellular Matrix
(ECM) maestros involved in the orchestration of multiple cellular events in physiology and …

Epitranscriptome analysis of oxidative stressed retinal epithelial cells depicted a possible RNA editing landscape of retinal degeneration

L Donato, C Scimone, S Alibrandi, SZ Scalinci… - Antioxidants, 2022 - mdpi.com
Oxidative stress represents one of the principal causes of inherited retinal dystrophies, with
many related molecular mechanisms still unknown. We investigated the posttranscriptional …

Binding of the SARS-CoV-2 spike protein to glycans

W Hao, B Ma, Z Li, X Wang, X Gao, Y Li, B Qin… - Science Bulletin, 2021 - Elsevier
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a high number of deaths in the world. To combat it, it is necessary to develop a better …

Effect of microgravity on endothelial cell function, angiogenesis, and vessel remodeling during wound healing

L Morbidelli, S Genah, F Cialdai - Frontiers in bioengineering and …, 2021 - frontiersin.org
Wound healing is a complex phenomenon that involves different cell types with various
functions, ie, keratinocytes, fibroblasts, and endothelial cells, all influenced by the action of …

Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease

A Basu, NG Patel, ED Nicholson… - American Journal of …, 2022 - journals.physiology.org
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously
expressed on the cell surface and in the extracellular matrix of all animal cells. These …

Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function

H Maldonado, BD Savage, HR Barker, U May… - Nature …, 2023 - nature.com
CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels.
Here we discover that systemically administered CAR peptide has inherent ability to …

Syndecan receptors: pericellular regulators in development and inflammatory disease

S Gopal, S Arokiasamy, C Pataki… - Open …, 2021 - royalsocietypublishing.org
The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

Polysaccharides catabolism by the human gut bacterium -Bacteroides thetaiotaomicron: advances and perspectives

M Ye, J Yu, X Shi, J Zhu, X Gao… - Critical reviews in food …, 2021 - Taylor & Francis
In recent years, the degradation processes of polysaccharides by human gut microbiota are
receiving considerable attention due to the discoveries of the powerful function of gut …