Tauopathies: new perspectives and challenges

Y Zhang, KM Wu, L Yang, Q Dong, JT Yu - Molecular Neurodegeneration, 2022‏ - Springer
Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …

Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies

M Stamelou, G Respondek, N Giagkou… - Nature Reviews …, 2021‏ - nature.com
Tauopathies are classified according to whether tau deposits predominantly contain tau
isoforms with three or four repeats of the microtubule-binding domain. Those in which four …

Neuropathology and emerging biomarkers in corticobasal syndrome

S Koga, KA Josephs, I Aiba, M Yoshida… - Journal of Neurology …, 2022‏ - jnnp.bmj.com
Corticobasal syndrome (CBS) is a clinical syndrome characterised by progressive
asymmetric limb rigidity and apraxia with dystonia, myoclonus, cortical sensory loss and …

Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration

A Benussi, TK Karikari, N Ashton, S Gazzina… - Journal of Neurology …, 2020‏ - jnnp.bmj.com
Objective To assess the diagnostic and prognostic value of serum neurofilament light (NfL)
and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal …

Validation of α‐synuclein in L1CAM‐immunocaptured exosomes as a biomarker for the stratification of parkinsonian syndromes

C Jiang, F Hopfner, D Berg, MT Hu, A Pilotto… - Movement …, 2021‏ - Wiley Online Library
Background Parkinson's disease is characterized by intraneuronal α‐synuclein aggregation.
Currently there is no α‐synuclein‐based blood test in clinical practice. Objectives Our aim …

Lewy body disease or diseases with Lewy bodies?

K Menšíková, R Matěj, C Colosimo, R Rosales… - npj Parkinson's …, 2022‏ - nature.com
The current nosological concept of α-synucleinopathies characterized by the presence of
Lewy bodies (LBs) includes Parkinson's disease (PD), Parkinson's disease dementia (PDD) …

Cortical [18F]PI‐2620 Binding Differentiates Corticobasal Syndrome Subtypes

C Palleis, M Brendel, A Finze, E Weidinger… - Movement …, 2021‏ - Wiley Online Library
Background Corticobasal syndrome is associated with cerebral protein aggregates
composed of 4‐repeat (~ 50% of cases) or mixed 3‐repeat/4‐repeat tau isoforms (~ 25% of …

Fluid biomarkers in frontotemporal dementia: past, present and future

IJ Swift, A Sogorb-Esteve, C Heller… - Journal of Neurology …, 2021‏ - jnnp.bmj.com
The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a
heterogeneous group of conditions. However, following on from a series of important …

Evaluating the effect of Alzheimer's disease‐related biomarker change in corticobasal syndrome and progressive supranuclear palsy

I Garcia‐Cordero, C Anastassiadis, A Khoja… - Annals of …, 2024‏ - Wiley Online Library
Objectives To evaluate the effect of Alzheimer's disease (AD)‐related biomarker change on
clinical features, brain atrophy and functional connectivity of patients with corticobasal …

Synaptic Loss in Primary Tauopathies Revealed by [11C]UCB‐J Positron Emission Tomography

N Holland, PS Jones, G Savulich… - Movement …, 2020‏ - Wiley Online Library
Background Synaptic loss is a prominent and early feature of many neurodegenerative
diseases. Objectives We tested the hypothesis that synaptic density is reduced in the …