The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …

Neurovascular coupling is a crucial mechanism that matches the high energy demand of the
brain with a supply of energy substrates from the blood. Signaling within the neurovascular …

Microglia survey brain parenchyma, responding to injury and infections. Microglia also
respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this …

Astrocytes are essential for normal brain development and functioning. They respond to
brain injury and disease through a process referred to as reactive astrogliosis, where the …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …

The neurovascular unit (NVU) is a relatively recent concept that clearly describes the
relationship between brain cells and their blood vessels. The components of the NVU …

A neuroinflammatory reaction in Alzheimer disease (AD) brains involves reactive astrocytes
that overexpress monoamine oxidase-B (MAO-B). 18F-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2 …

Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure
proper brain function. The adult human brain represents only a small portion of the body …

Autophagy is a major degradation pathway where double-membrane vesicles called
autophagosomes deliver cytoplasmic content to the lysosome. Increasing evidence …