The development of bioactive small molecules as probes or drug candidates requires
discovery platforms that enable access to chemical diversity and can quickly reveal new …

Carbonic anhydrase (CA, EC 4.2. 1.1) is a protein that is especially well-suited to serve as a
model in many types of studies in biophysics, bioanalysis, the physical-organic chemistry of …

Here we describe a phage strategy for the selection of ligands based on bicyclic or linear
peptides attached covalently to an organic core. We designed peptide repertoires with three …

The translation of nucleic acid libraries into corresponding synthetic compounds would
enable selection and amplification principles to be applied to man-made molecules. We …

DNA-encoded libraries have emerged as a widely used resource for the discovery of
bioactive small molecules, and offer substantial advantages compared with conventional …

In contrast to the approach commonly taken by chemists, nature controls chemical reactivity
by modulating the effective molarity of highly dilute reactants through macromolecule …

The isolation of molecules capable of high-affinity and specific binding to biological targets
is a central problem in chemistry, biology and pharmaceutical sciences. Here we describe …

Researchers seeking to improve the efficiency and cost effectiveness of the bioactive small-
molecule discovery process have recently embraced selection-based approaches, which in …

Sensing nucleic acid sequences is critical in modern-day biology and medicine, and is likely
to continue to increase in importance over the next 10r20 years. The current uses for …

Small-molecule-linked DNA has emerged as a versatile tool for the interaction assay
between small organic molecules and their protein receptors. We report herein the proof-of …