The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …

Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Cellular processes can only be understood as the dynamic interplay of molecules. There is a
need for techniques to monitor interactions of endogenous proteins directly in individual …

Dynamic networks of protein–protein interactions regulate numerous cellular processes and
determine the ability to respond appropriately to environmental stimuli. However, the …

Myc (avian myelocytomatosis viral oncogene homolog) represents one of the most sought
after drug targets in cancer. Myc transcription factor is an essential regulator of cell growth …

The role of the myc gene family in the biology of normal and cancer cells has been
intensively studied since the early 1980s. myc genes, responding to diverse external and …

The specificity of intracellular signaling and developmental patterning in biological systems
relies on selective interactions between different proteins in specific cellular compartments …

Protein interactions are a fundamental mechanism for the generation of biological regulatory
specificity. The study of protein interactions in living cells is of particular significance …

Regulation of the MYC oncogene remains unclear. Using 10058-F4, a compound that
inhibits MYC-MAX transcription factor, MYC protein and gene expression were down …