[HTML][HTML] Mitochondrial biogenesis, mitochondrial dynamics, and mitophagy in the maturation of cardiomyocytes
Q Ding, Y Qi, SY Tsang - Cells, 2021 - mdpi.com
Pluripotent stem cells (PSCs) can undergo unlimited self-renewal and can differentiate into
all the cell types present in our body, including cardiomyocytes. Therefore, PSCs can be an …
all the cell types present in our body, including cardiomyocytes. Therefore, PSCs can be an …
[HTML][HTML] Toward building mass spectrometry-based metabolomics and lipidomics atlases for biological and clinical research
Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …
Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells
Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an
important therapeutic target population for modeling and treating cardiovascular diseases …
important therapeutic target population for modeling and treating cardiovascular diseases …
[HTML][HTML] BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice
Zebrafish have a lifelong cardiac regenerative ability after damage, whereas mammals lose
this capacity during early postnatal development. This study investigated whether the …
this capacity during early postnatal development. This study investigated whether the …
Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration
Background: Cardiac regeneration after injury is limited by the low proliferative capacity of
adult mammalian cardiomyocytes (CMs). However, certain animals readily regenerate lost …
adult mammalian cardiomyocytes (CMs). However, certain animals readily regenerate lost …
m6A modification promotes miR-133a repression during cardiac development and hypertrophy via IGF2BP2
B Qian, P Wang, D Zhang, L Wu - Cell Death Discovery, 2021 - nature.com
Abstract Both N6-methyladenosine (m6A) RNA modification and microRNAs (miRNAs) are
common regulatory mechanisms for gene post-transcription by modulating mRNA stability …
common regulatory mechanisms for gene post-transcription by modulating mRNA stability …
Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration
In mammals, the physiological activation of the glucocorticoid receptor (GR) by
glucocorticoids (GCs) promotes the maturation of cardiomyocytes during late gestation, but …
glucocorticoids (GCs) promotes the maturation of cardiomyocytes during late gestation, but …
[HTML][HTML] Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development
Defining the mechanisms that govern heart development is essential for identifying the
etiology of congenital heart disease. Here, quantitative proteomics was used to measure …
etiology of congenital heart disease. Here, quantitative proteomics was used to measure …
The role of metabolism in heart failure and regeneration
Heart failure is the leading cause of death worldwide. The inability of the adult mammalian
heart to regenerate following injury results in the development of systolic heart failure. Thus …
heart to regenerate following injury results in the development of systolic heart failure. Thus …
Time-dependent effects of BRAF-V600E on cell cycling, metabolism, and function in engineered myocardium
Candidate cardiomyocyte (CM) mitogens such as those affecting the extracellular signal–
regulated kinase (ERK) signaling pathway represent potential targets for functional heart …
regulated kinase (ERK) signaling pathway represent potential targets for functional heart …