Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Bone metastases (BM) are a common complication of cancer, whose management often
requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with …

Bone metastasis is a major cause of morbidity in persons with cancer. Complications include
pain, impaired mobility, pathological fracture, spinal cord compression, cranial nerve …

The number of patients with bone metastasis increases as medical management and
surgery improve the overall survival of patients with cancer. Bone metastasis can cause …

Bone metastases are frequently the final fate of breast and prostate cancer patients.
According to the definition of metastasis as an incurable disease, to date there are no …

Cysteine cathepsins have been for a long time considered to execute mainly nonspecific
bulk proteolysis in the endolysosomal system. However, this view has been changing …

Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Abstract α, α-Bisphosphonates (BPs) are well established in the treatment of bone diseases
such as osteoporosis and Paget's disease. Their successful application originates from their …

Background Bone is one of the most common target organs for cancer metastasis, especially
in patients with advanced breast and prostate cancers. Despite recent advances in …

Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is
associated with poor long-term survival, and has limited therapeutic options. Sclerostin …