Targeting CDK4 and CDK6 in cancer
S Goel, JS Bergholz, JJ Zhao - Nature Reviews Cancer, 2022 - nature.com
Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …
transition into S phase and are important for the initiation, growth and survival of many …
Cellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer
AC Watt, S Goel - Breast Cancer Research, 2022 - Springer
Pharmacological inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are now an
established standard of care for patients with advanced hormone receptor-positive breast …
established standard of care for patients with advanced hormone receptor-positive breast …
Mammalian cyclin-dependent kinases
Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian
heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle …
heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle …
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition
The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …
[HTML][HTML] CDK4: a master regulator of the cell cycle and its role in cancer
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
[BUCH][B] Structure and function of intrinsically disordered proteins
The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …
classical structure-function paradigm that equates function with a well-defined 3D structure …
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities
G He, ZH Siddik, Z Huang, R Wang, J Koomen… - Oncogene, 2005 - nature.com
DNA damage often activates the p53–p21 pathway and causes G 1-phase arrest in
mammalian cells. Although there is ample evidence that p21 induction by p53 leads to Cdk2 …
mammalian cells. Although there is ample evidence that p21 induction by p53 leads to Cdk2 …
CDK4: a key player in the cell cycle, development, and cancer
The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …
p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a
P Krimpenfort, A IJpenberg, JY Song, M van der Valk… - Nature, 2007 - nature.com
The CDKN2b–CDKN2a locus on chromosome 9p21 in human (chromosome 4 in mouse) is
frequently lost in cancer. The locus encodes three cell cycle inhibitory proteins: p15INK4b …
frequently lost in cancer. The locus encodes three cell cycle inhibitory proteins: p15INK4b …
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
L Song, M Morris, T Bagui, FY Lee, R Jove, EB Haura - Cancer research, 2006 - AACR
Mutations of the epidermal growth factor receptor (EGFR) selectively activate Akt and signal
transducer and activator of transcription (STAT) pathways that are important in lung cancer …
transducer and activator of transcription (STAT) pathways that are important in lung cancer …