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Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport—an update
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer
K Fujita, Y Kubota, H Ishida… - World journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …
[HTML][HTML] Genophenotypic factors and pharmacogenomics in adverse drug reactions
R Cacabelos, V Naidoo, L Corzo, N Cacabelos… - International journal of …, 2021 - mdpi.com
Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …
illness in developed countries. ADRs show differential features depending upon genotype …
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in …
Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …
development time and application review time. The former factor is still an important problem …
Phase II study of neoadjuvant chemotherapy and extended surgery for locally advanced gastric cancer
Background Locally advanced gastric cancer with extensive lymph node metastasis is
usually considered unresectable and so treated by chemotherapy. This trial explored the …
usually considered unresectable and so treated by chemotherapy. This trial explored the …
Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review
UDP-glucuronosyltransferases (UGT) catalyze the biotransformation of many endobiotics
and xenobiotics, and are coded by polymorphic genes. However, knowledge about the …
and xenobiotics, and are coded by polymorphic genes. However, knowledge about the …
The safety and efficacy of Onivyde (irinotecan liposome injection) for the treatment of metastatic pancreatic cancer following gemcitabine-based therapy
Introduction: Patients with advanced and metastatic pancreatic cancer refractory to
gemcitabine based therapy have a dismal prognosis and limited therapeutic options …
gemcitabine based therapy have a dismal prognosis and limited therapeutic options …
Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years
During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …
showing its high degree of inter-individual differentiation, as a result of large international …
UGT1A1 polymorphisms in cancer: impact on irinotecan treatment
M Takano, T Sugiyama - Pharmacogenomics and personalized …, 2017 - Taylor & Francis
Mutations in the UGT1A1 gene have been implicated in Gilbert syndrome, which shows mild
hyperbilirubinemia, and a more aggressive childhood subtype, Crigler–Najjar syndrome. To …
hyperbilirubinemia, and a more aggressive childhood subtype, Crigler–Najjar syndrome. To …
Clinically relevant genetic variations in drug metabolizing enzymes
In the field of pharmacogenetics, we currently have a few markers to guide physicians as to
the best course of therapy for patients. For the most part, these genetic variants are within a …
the best course of therapy for patients. For the most part, these genetic variants are within a …