The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …

Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …

Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

Background Locally advanced gastric cancer with extensive lymph node metastasis is
usually considered unresectable and so treated by chemotherapy. This trial explored the …

UDP-glucuronosyltransferases (UGT) catalyze the biotransformation of many endobiotics
and xenobiotics, and are coded by polymorphic genes. However, knowledge about the …

Introduction: Patients with advanced and metastatic pancreatic cancer refractory to
gemcitabine based therapy have a dismal prognosis and limited therapeutic options …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Mutations in the UGT1A1 gene have been implicated in Gilbert syndrome, which shows mild
hyperbilirubinemia, and a more aggressive childhood subtype, Crigler–Najjar syndrome. To …

In the field of pharmacogenetics, we currently have a few markers to guide physicians as to
the best course of therapy for patients. For the most part, these genetic variants are within a …