Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlap** processes, as successfully metastasizing cells assume …

To understand the function of cortical circuits, it is necessary to catalog their cellular
diversity. Past attempts to do so using anatomical, physiological or molecular features of …

Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human
patients with cancer whose tumours are driven by RAS mutations,. RMC-7977 is a highly …

High-throughput chemical screens typically use coarse assays such as cell survival, limiting
what can be learned about mechanisms of action, off-target effects, and heterogeneous …

There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …

Genomic instability can trigger cancer-intrinsic innate immune responses that promote tumor
rejection. However, cancer cells often evade these responses by overexpressing immune …

Tissue-resident memory T cells (TRM) maintain immunity in diverse sites as determined in
mouse models, whereas their establishment and role in human tissues have been difficult to …

Drug toxicity evaluation is an essential process of drug development as it is reportedly
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …

Here we report Digital RNA with pertUrbation of Genes (DRUG-seq), a high-throughput
platform for drug discovery. Pharmaceutical discovery relies on high-throughput screening …

Assays to study cancer cell responses to pharmacologic or genetic perturbations are
typically restricted to using simple phenotypic readouts such as proliferation rate. Information …