More than meets the eye in Parkinson's disease and other synucleinopathies: from proteinopathy to lipidopathy
The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …
Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies
Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that
protects the brain and spinal cord against mechanical shock, provides buoyancy, clears …
protects the brain and spinal cord against mechanical shock, provides buoyancy, clears …
Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
A Blandin, I Dugail, G Hilairet, M Ponnaiah… - Cell reports, 2023 - cell.com
Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the
development of obesity-related metabolic dysfunctions. This study aims to define mouse …
development of obesity-related metabolic dysfunctions. This study aims to define mouse …
Update on CSF biomarkers in Parkinson's disease
Progress in develo** disease-modifying therapies in Parkinson's disease (PD) can only
be achieved through reliable objective markers that help to identify subjects at risk. This …
be achieved through reliable objective markers that help to identify subjects at risk. This …
[HTML][HTML] Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments
ME Gegg, E Menozzi, AHV Schapira - Neurobiology of Disease, 2022 - Elsevier
Dysfunction of the endolysosomal system is implicated in the pathogenesis of both sporadic
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …
and familial Parkinson disease (PD). Variants in genes encoding lysosomal proteins have …
Lipid metabolism influence on neurodegenerative disease progression: is the vehicle as important as the cargo?
RE Estes, B Lin, A Khera, MY Davis - Frontiers in molecular …, 2021 - frontiersin.org
Many neurodegenerative diseases are characterized by abnormal protein aggregates,
including the two most common neurodegenerative diseases Alzheimer's disease (AD) and …
including the two most common neurodegenerative diseases Alzheimer's disease (AD) and …
[HTML][HTML] Targeting the GBA1 pathway to slow Parkinson disease: Insights into clinical aspects, pathogenic mechanisms and new therapeutic avenues
E Menozzi, M Toffoli, AHV Schapira - Pharmacology & therapeutics, 2023 - Elsevier
The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase), which is
involved in sphingolipid metabolism. Biallelic variants in GBA1 cause Gaucher disease …
involved in sphingolipid metabolism. Biallelic variants in GBA1 cause Gaucher disease …
GBA-associated PD: chances and obstacles for targeted treatment strategies
Given the clear role of GBA in the pathogenesis of Parkinson's disease (PD) and its impact
on phenotypical characteristics, this review provides an overview of the current knowledge …
on phenotypical characteristics, this review provides an overview of the current knowledge …
Retinal pigment epithelium extracellular vesicles are potent inducers of age‐related macular degeneration disease phenotype in the outer retina
Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is
caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal …
caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal …
Circulating sphingolipids and glucose homeostasis: an update
S Ali-Berrada, J Guitton, S Tan-Chen… - International Journal of …, 2023 - mdpi.com
Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …
mammals. Sphingolipids are structural components of membranes, but in response to …