Certain metabolic interventions such as caloric restriction, fasting, exercise, and a ketogenic
diet extend lifespan and/or health span. However, their benefits are limited and their …

Replacement of serum and increasing use of chemically defined media demands
optimisation of trace metal components for biomanufacturing applications. Trace metal …

Aims To understand the mechanism by which imeglimin (a new oral hypoglycemic agent
whose phase 3 development program in Japan has now been completed) decreases …

Cytosolic phosphoenolpyruvate carboxykinase (PCK1) is considered a gluconeogenic
enzyme; however, its metabolic functions and regulatory mechanisms beyond …

Cancer cells are reprogrammed to consume large amounts of glucose to support anabolic
biosynthetic pathways. However, blood perfusion and consequently the supply with glucose …

Carbon black nanoparticles (CBNPs) are core component of fine particulate matter (PM2. 5)
in the atmosphere. It was reported that the particle in the atmosphere with smaller size and …

Inorganic arsenic (iAs) is a widespread contaminant in marine environments, which is
present in two different oxidation states (arsenate (AsV) and arsenite (AsIII)) that have …

Four female Shetland Sheepdogs with hypertonic paroxysmal dyskinesia, mainly triggered
by exercise and stress, were investigated in a retrospective multi-center investigation aiming …

The process of muscle development and intramuscular fat (IMF) deposition is quite complex
and controlled by both mRNAs and ncRNAs. Long-stranded non-coding RNAs (LncRNAs) …

This review describes our current understanding of the role of the mitochondria in the
repurposing of the anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and …