Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review

LF van Schaik, EG Engelhardt, EA Wilthagen… - Critical reviews in …, 2024 - Elsevier
Abstract Comprehensive Genomic Profiling (CGP) allows for the identification of many
targets. Reimbursement decision-making is, however, challenging because besides the …

First-line genomic profiling in previously untreated advanced solid tumors for identification of targeted therapy opportunities

J Matsubara, K Mukai, T Kondo, M Yoshioka… - JAMA Network …, 2023 - jamanetwork.com
IMPORTANCE Precision oncology using comprehensive genomic profiling (CGP) by next-
generation sequencing is aimed at companion diagnosis and genomic profiling. The clinical …

Administrative aspects of molecular diagnostics—Oversight, regulatory approval process, clinical and operational workflows, and payment models

L Wilfong, L Baggett, P Reena, R Murphy… - JCO Oncology …, 2024 - ascopubs.org
This paper discusses the administrative aspects of molecular diagnostics in oncology,
including US Food and Drug Administration (FDA) oversight, the regulatory approval …

Clinical impact of comprehensive molecular profiling in adolescents and young adults with sarcoma

EC Andrew, J Lewin, J Desai, L Orme… - Journal of Personalized …, 2024 - mdpi.com
Sarcomas are a heterogenous group of tumours that commonly carry poor prognosis with
limited therapeutic options. Adolescents and young adults (AYAs) with sarcoma are a …

Real-World Impact of Comprehensive Genomic Profiling on Biomarker Detection, Receipt of Therapy, and Clinical Outcomes in Advanced Non–Small Cell Lung …

J Wallenta Law, B Bapat, C Sweetnam… - JCO Precision …, 2024 - ascopubs.org
PURPOSE Therapeutic decision making for patients with advanced non–small cell lung
cancer (aNSCLC) includes a growing number of options for genomic, biomarker-guided …

Examining external control arms in oncology: A sco** review of applications to date

E Farah, M Kenney, MT Warkentin… - Cancer …, 2024 - Wiley Online Library
Abstract Objectives Randomized controlled trials (RCTs) are the gold standard for
evaluating the comparative efficacy and safety of new cancer therapies. However, enrolling …

[HTML][HTML] Longer survival with precision medicine in late-stage cancer patients

CK Mapendano, AK Nøhr, M Sønderkær, A Pagh… - ESMO open, 2025 - Elsevier
Background In a per-protocol analysis of molecularly profiled patients with treatment-
refractory, end-stage cancer discussed at the National Molecular Tumor Board (NMTB), we …

Comprehensive genomic profiling of Taiwanese triple negative breast cancers with medium-and large-sized sequencing panels: a comparative study of actionable …

CC Huang, YC Yeh, YF Tsai, YS Lin, TC Chao, CY Liu… - 2024 - researchsquare.com
Methods Triple negative breast cancer (TNBC) patients from the VGH-TAYLOR study were
initially assayed by a medium-sized CGP panel (Oncomine Comprehensive Panel, OCP …