Protein secretion is a basic cellular function found in organisms of all kingdoms of life. Gram-
negative bacteria have evolved a remarkable number of pathways for the transport of …

Bacterial surface display entails the presentation of recombinant proteins or peptides on the
surface of bacterial cells. Escherichia coli is the most frequently used bacterial host for …

Much remains unknown about how the intestinal microbiome interfaces with the protective
intestinal mucus layer. Bifidobacterium species colonize the intestinal mucus layer and can …

Bacteria can sense their environment, distinguish between cell types, and deliver proteins to
eukaryotic cells. Here, we engineer the interaction between bacteria and cancer cells to …

We describe a proteomic approach for identifying bacterial surface-exposed proteins quickly
and reliably for their use as vaccine candidates. Whole cells are treated with proteases to …

We have identified a homologue to the staphylococcal biofilm-associated protein (Bap) in a
bloodstream isolate of Acinetobacter baumannii. The fully sequenced open reading frame is …

The myriad microorganisms that live in close association with humans have diverse effects
on physiology, yet the molecular bases for these impacts remain mostly unknown …

Trimeric autotransporter adhesins (TAAs) are important virulence factors in Gram-negative
pathogens. Despite the variety of hosts ranging from plants to mammals and the specialized …

The genome of the human food-borne pathogen Listeria monocytogenes is predicted to
encode a high number of surface proteins. This abundance likely reflects the ability of this …

The ability of the human body to play host to bacterial pathogens has been studied for more
than 200 years. Successful pathogenesis relies on the ability to acquire the nutrients that are …