Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology

M Hesami, M Pepe, A Baiton, AMP Jones - Biotechnology Advances, 2023 - Elsevier
For centuries, cannabis has been a rich source of fibrous, pharmaceutical, and recreational
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …

Microbial adaptation to enhance stress tolerance

YS Tan, RK Zhang, ZH Liu, BZ Li, YJ Yuan - Frontiers in Microbiology, 2022 - frontiersin.org
Microbial cell factories have been widely used in the production of various chemicals.
Although synthetic biology is useful in improving the cell factories, adaptation is still widely …

Parallel evolution of cannabinoid biosynthesis

P Berman, LA de Haro, A Jozwiak, S Panda, Z Pinkas… - Nature plants, 2023 - nature.com
Modulation of the endocannabinoid system is projected to have therapeutic potential in
almost all human diseases. Accordingly, the high demand for novel cannabinoids stimulates …

Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis

Z **e, Y Mi, L Kong, M Gao, S Chen… - Horticulture …, 2023 - academic.oup.com
Is Cannabis a boon or bane? Cannabis sativa has long been a versatile crop for fiber
extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational …

[HTML][HTML] The neurotherapeutic arsenal in Cannabis sativa: Insights into anti-neuroinflammatory and neuroprotective activity and potential entourage effects

AK Al-Khazaleh, X Zhou, DJ Bhuyan, GW Münch… - Molecules, 2024 - mdpi.com
Cannabis, renowned for its historical medicinal use, harbours various bioactive compounds—
cannabinoids, terpenes, and flavonoids. While major cannabinoids like delta-9 …

Development of an efficient yeast platform for cannabigerolic acid biosynthesis

Y Zhang, J Guo, PZ Gao, W Yan, J Shen, X Luo… - Metabolic …, 2023 - Elsevier
Cannabinoids are important therapeutical molecules for human ailments, cancer treatment,
and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from …

Xanthone biosynthetic pathway in plants: a review

J Remali, I Sahidin, WM Aizat - Frontiers in Plant Science, 2022 - frontiersin.org
Xanthones are secondary metabolites rich in structural diversity and possess a broad array
of pharmacological properties, such as antitumor, antidiabetic, and anti-microbes. These …

[HTML][HTML] Understanding Cannabis sativa L.: Current Status of Propagation, Use, Legalization, and Haploid-Inducer-Mediated Genetic Engineering

DC Simiyu, JH Jang, OR Lee - Plants, 2022 - mdpi.com
Cannabis sativa L. is an illegal plant in many countries. The worldwide criminalization of the
plant has for many years limited its research. Consequently, understanding the full scope of …

[HTML][HTML] Building a biofactory: Constructing glandular trichomes in Cannabis sativa

J Hancock, SJ Livingston, L Samuels - Current Opinion in Plant Biology, 2024 - Elsevier
Flowers of Cannabis sativa L. are densely covered with glandular trichomes containing
cannabis resin that is used for medicinal and recreational purposes. The highly productive …

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in Nicotiana benthamiana

D Grzech, B Hong, L Caputi, PD Sonawane… - ACS synthetic …, 2022 - ACS Publications
Vinblastine is a chemotherapy agent produced by the plant Catharanthus roseus in small
quantities. Currently, vinblastine is sourced by isolation or semisynthesis. Nicotiana …