The immune response holds a pivotal role in cardiovascular disease development. As
multifunctional cells of the innate immune system, macrophages play an essential role in …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Aims Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic
cells (DCs)] in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell …

Atherosclerotic cardiovascular disease is a major cause of disability and death worldwide.
Most therapeutic approaches target traditional risk factors but ignore the fundamental role of …

Cholesterol-overloaded cells or “foam cells” in the artery wall are the biochemical hallmark
of atherosclerosis, and are responsible for much of the growth, inflammation and …

An incomplete understanding of the cellular functions and underlying mechanisms of zinc
ions released from zinc‐based stents in atherosclerosis (AS) therapy is one of the major …

Technology at the single‐cell level has advanced dramatically in characterizing molecular
heterogeneity. These technologies have enabled cell subtype diversity to be seen in all …

BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs)
disease, including brain bleedings and thrombosis that cause neurological disabilities in …

Background Endothelial cell (EC) metabolism plays a crucial role in the process of
angiogenesis. Intrinsic metabolic events such as glycolysis, fatty acid oxidation, and …

Purpose Despite an increase in treatment options, and substantial reductions in
cardiovascular mortality over the past half-century, atherosclerosis remains the most …