Caenorhabditis elegans survives on ephemeral food sources in the wild, and the species
has a variety of adaptive responses to starvation. These features of its life history make the …

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively
utilized as an animal model for research involving aging and neurodegenerative diseases …

Low energy states delay aging in multiple species, yet mechanisms coordinating energetics
and longevity across tissues remain poorly defined. The conserved energy sensor AMP …

Dietary restriction (DR) delays aging and the onset of age-associated diseases. However, it
is yet to be determined whether and how restriction of specific nutrients promote longevity …

Life cycle delays are beneficial for opportunistic species encountering suboptimal
environments. Many animals display a programmed arrest of development (diapause) at …

Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

Diet affects nearly every aspect of animal life such as development, metabolism, behavior,
and aging, both directly by supplying nutrients and indirectly through gut microbiota. C …

Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major
driver of body fat loss. However, mechanisms by which central serotonin action leads to fat …

The kynurenine pathway of tryptophan metabolism is involved in the pathogenesis of
several brain diseases, but its physiological functions remain unclear. We report that …

Background Metabolic activity alternates between high and low states during different
stages of an organism's life cycle. During the transition from growth to quiescence, a major …