Mechanisms of disease: inflammatory bowel diseases

GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …

Why is initial bacterial colonization of the intestine important to infants' and children's health?

PD Houghteling, WA Walker - Journal of pediatric …, 2015 - journals.lww.com
Microbial colonization of the infant occurs during a critical time window for immune and
gastrointestinal development. Infant colonization sets the stage for the adult microbiome …

A clinical review of recent findings in the epidemiology of inflammatory bowel disease

A Ponder, MD Long - Clinical epidemiology, 2013 - Taylor & Francis
Inflammatory bowel diseases (IBD), including both Crohn's disease and ulcerative colitis,
are disorders of chronic inflammation of the gastrointestinal tract marked by episodes of …

The role of environmental factors in the pathogenesis of inflammatory bowel diseases: a review

DS Shouval, PA Rufo - JAMA pediatrics, 2017 - jamanetwork.com
Importance Inflammatory bowel diseases (IBD), such as Crohn disease and ulcerative
colitis, are chronic relapsing conditions that affect a growing number of children worldwide …

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

LJ Wammes, H Mpairwe, AM Elliott… - The Lancet Infectious …, 2014 - thelancet.com
Deworming is rightly advocated to prevent helminth-induced morbidity. Nevertheless, in
affluent countries, the deliberate infection of patients with worms is being explored as a …

The role of gastrointestinal pathogens in inflammatory bowel disease: a systematic review

JE Axelrad, KH Cadwell… - Therapeutic …, 2021 - journals.sagepub.com
The inflammatory bowel diseases (IBD), comprising Crohn's disease (CD) and ulcerative
colitis (UC), are chronic, progressive, inflammatory conditions of the gastrointestinal tract …

Eosinophils and helminth infection: protective or pathogenic?

E Mitre, AD Klion - Seminars in immunopathology, 2021 - Springer
Since the earliest descriptions of this enigmatic cell, eosinophils have been implicated in
both protective and pathogenic immune responses to helminth infection. Nevertheless …

[HTML][HTML] The underrated gut microbiota helminths, bacteriophages, fungi, and archaea

MJ Garcia-Bonete, A Rajan, F Suriano, E Layunta - Life, 2023 - mdpi.com
The microbiota inhabits the gastrointestinal tract, providing essential capacities to the host.
The microbiota is a crucial factor in intestinal health and regulates intestinal physiology …

Immunomodulatory and biological properties of helminth-derived small molecules: Potential applications in diagnostics and therapeutics

K Yeshi, R Ruscher, A Loukas… - Frontiers in Parasitology, 2022 - frontiersin.org
Parasitic helminths secrete and excrete a vast array of molecules known to help skew or
suppress the host's immune response, thereby establishing a niche for sustained parasite …

Systematic review: gastrointestinal infection and incident inflammatory bowel disease

JE Axelrad, KH Cadwell, JF Colombel… - Alimentary …, 2020 - Wiley Online Library
Background The initiating events of chronic gastrointestinal (GI) inflammation in Crohn's
disease (CD) and ulcerative colitis (UC) are not well‐defined, but GI infections are …