During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

“The Tao begets the One. One begets all things of the world.” This quote from Tao Te Ching
is still inspiring for scientists in chemistry and materials science: The “One” can refer to a …

Receptor–ligand interactions are essential for biological function and their binding strength
is commonly explained in terms of static lock-and-key models based on molecular …

Simulations with adaptive time-dependent bias enable an efficient exploration of the
conformational space of a system. However, the dynamic information is altered by the bias …

Our ability to calculate rate constants of biochemical processes using molecular dynamics
simulations is severely limited by the fact that the time scales for reactions, or changes in …

While many fields have contributed to biological physics, nanotechnology offers a new scale
of observation. High-speed atomic force microscopy (HS-AFM) provides nanometre …

The force-dependent unfolding/refolding of protein domains and ligand-receptor
association/dissociation are crucial for mechanosensitive functions, while many aspects of …

The Sec translocon moves proteins across lipid bilayers in all cells. The Sec channel
enables passage of unfolded proteins through the bacterial plasma membrane, driven by …

Complete understanding of the role of mechanical forces in biological processes requires
knowledge of the mechanical properties of individual proteins and living cells. Moreover, the …

Biomolecular interactions are at the base of all physical processes within living organisms;
the study of these interactions has led to the development of a plethora of different methods …