The prevalence and cost of chronic pain is a major physical and mental health care problem
in the United States today. As a result, there has been a recent explosion of research on …

Although modern techniques such as two-photon microscopy can now provide cellular-level
three-dimensional imaging of the intact living brain, the speed and fields of view of these …

Optical brain imaging has seen 30 years of intense development, and has grown into a rich
and diverse field. In-vivo imaging using light provides unprecedented sensitivity to functional …

Fast fMRI enables the detection of neural dynamics over timescales of hundreds of
milliseconds, suggesting it may provide a new avenue for studying subsecond neural …

The brain functions through coordinated activity among distributed regions. Wide-field
calcium imaging, combined with improved genetically encoded calcium indicators, allows …

Hemodynamic changes in the brain are often used as surrogates of neuronal activity to infer
the loci of brain activity. A major limitation of conventional Doppler ultrasound for the …

Widefield imaging with genetically encoded voltage indicators (GEVIs) is a promising
approach for understanding the role of large cortical networks in the neural coding of …

Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity,
and other baseline physiologies and eventually modifies the neurovascular coupling …

The cortical hemodynamic response to somatosensory stimulus is investigated at the level of
individual vascular compartments using both depth-resolved optical imaging and in-vivo two …

Camera-based optical imaging of the exposed brain allows cortical hemodynamic
responses to stimulation to be examined. Typical multispectral imaging systems utilize a …